| 出品公司: | ATCC |
|---|---|
| 菌种名称: | ATCC20542, ATCC 20542 |
| 菌种又名: | MF4845 |
| 菌株类型: | 土生曲霉组;土曲霉;土生曲霉;土曲霉菌;菌土曲霉,Aspergillus terreus |
| 存储人: | Merck & Co., Inc. |
| 分离来源: | |
| 产品目录号: | 20542 |
| 其他保藏库编号: | BCRC32670,ATCC 20542 |
| 培养基: |
ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 324: Malt extract agar
ATCC® Medium 336: Potato dextrose agar (PDA)
|
| 生长条件: | 24-26 ℃, 有氧 |
| 生物安全等级: | 1 |
| 模式菌株: | 否 |
| 应用: | 科研，生产，主要用于产生低胆固醇药物,产生低血脂药物,产生洛伐他汀,生产Mevinolin,生产甲乙烯基甲酸 |
| 菌株特点: |
ATCC 20542是土曲霉,Aspergillus terreus 。Nucleotide (GenBank) : GU256759 ITS including 5.8S rRNA gene
Nucleotide (GenBank) : AABT00000000 Aspergillus terreus ATCC 20542, whole genome shotgun sequencing project
|
| 参考文献: |
Greenspan MD, Yudkovitz JB. Mevinolinic acid biosynthesis by Aspergillus terreus and its relationship to fatty acid biosynthesis. J. Bacteriol. 162: 704-707, 1985. PubMed: 3988710
Moore RN, et al. Biosynthesis of the hypocholesterolemic agent mevinolin by Aspergillus terreus. Determination of the origin of carbon, hydrogen, and oxygen atoms by 13C NMR and mass spectrometry. J. Am. Chem. Soc. 107: 3694-3701, 1985.
Lam TY. Hypocholesterolemic fermentation products. US Patent 4,376,863 dated Mar 15 1983
Hajko P, et al. Process for the isolation of lovastatin. US Patent 5,712,130 dated Jan 27 1998
Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77: 3957-3961, 1980. PubMed: 6933445
Askenazi M, et al. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains. Nat. Biotechnol. 21: 150-156, 2003.
Schierova M, Linka M, Pazoutova S. Sulfate assimilation in Aspergillus terreus: analysis of genes encoding ATP-sulfurylase and PAPS-reductase. Curr. Genet. 38: 126-131, 2000. PubMed: 11057445
Hendrickson L, et al. Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chem. Biol. 6: 429-439, 1999. PubMed: 10381407
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