| 出品公司: | ATCC |
|---|---|
| 菌种名称: | ATCC 27064, ATCC27064 |
| 菌种又名: | [NRRL 3585] |
| 菌株类型: | Streptomyces clavuligerus，带小棒链霉菌 |
| 存储人: | CE Higgens |
| 分离来源: | 土壤，南美 |
| 产品目录号: | 27064 |
| 其他保藏库编号: | AS 4.1611 =ATCC 27064 =BCRC 11518 =CBS 226.75 =DSM 40751 =KCTC 9095 =NBRC 13307 |
| 培养基: |
ATCC Medium 196: Yeast malt extract agar 酵母麦芽汁琼脂
ATCC Medium 1877: ISP Medium 1 ISP培养基1号
|
| 生长条件: | 30 ℃, 有氧 |
| 生物安全等级: | 1 |
| 基因组序列号: | ABJH00000000, CM000913, CM001015 |
| 基因组是否测序: | 是 |
| 模式菌株: | 是 |
| 应用: | 细胞提取物能够通过环化作用将苯乙酰-L-半胱氨酰-D-缬氨酸转变为苄青霉素 |
| 菌株特点: |
ATCC 27064是Streptomyces clavuligerus，带小棒链霉菌。
Nucleotide (GenBank) : A38835 Sequence 2 from Patent WO9412654.
Nucleotide (GenBank) : A39664 Sequence 1 from Patent WO9418326.
Nucleotide (GenBank) : A42941 Sequence 2 from Patent WO9503416.
Nucleotide (GenBank) : AJ000671 Streptomyces clavuligerus car and claR genes.
Nucleotide (GenBank) : AJ001743 Streptomyces clavuligerus pcd, cmcT and pbp2 genes.
Nucleotide (GenBank) : Z81324 S.clavuligerus ccaR and blp genes and open open reading frame.
Nucleotide (GenBank) : AF038457 Streptomyces clavuligerus strain ATCC 27064 plasmid pSCL2 terminus.
Nucleotide (GenBank) : L06213 Streptomyces clavuligerus clavaminate synthase 1 (cs1) gene, complete cds.
Nucleotide (GenBank) : Z49111 Streptomyces clavuligerus arginine biosynthesis cluster (argCJBDRGH genes).
Nucleotide (GenBank) : AJ238211 Streptomyces clavuligerus ORF1, encoding a protein involved in clavulanic acid biosynthesis.
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| 参考文献: |
Luengo JM, et al. Cyclization of phenylacetyl-L-cysteinyl-D-valine to benzylpenicillin using cell-free extracts of Streptomyces clavuligerus. J. Antibiot. 39: 1144-1147, 1986. PubMed: 3759664
Baldwin JE, et al. Isolation and partial characterization of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase. J. Antibiot. 44: 241-248, 1991. PubMed: 2010361
Zhang J, Demain AL. Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway of carbon sources and their metabolites. Arch. Microbiol. 158: 364-369, 1992.
Howarth TT, et al. Antibiotics. US Patent 4,525,352 dated Jun 25 1985
Perez-Llarena FJ, et al. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Strptomyces clavuligerus: amplification results in overproduction of both beta-Lactam compounds. J. Bacteriol. 179: 2053-2059, 1997. PubMed: 9068654
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