| 出品公司: | ATCC |
|---|---|
| 菌种名称: | ATCC 34921, ATCC34921 |
| 菌种又名: | NRRL 8044 [FERM-P 2796] |
| 菌株类型: | Tolypocladium inflatum,丝状真菌,多孢木霉 |
| 存储人: | NRRL |
| 分离来源: | 土壤 |
| 产品目录号: | 34921 |
| 其他保藏库编号: | BCRC33530,ATCC 34921 ;NRRL 8044 ;FERM-P 2796 |
| 培养基: |
ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 336: Potato dextrose agar (PDA)
|
| 生长条件: | 24-26℃, 有氧 |
| 生物安全等级: | 1 |
| 模式菌株: | 否 |
| 应用: | 科研，生产,产生几丁质酶,产生环孢菌素A S-7481/F-1,产生环孢菌素B S-7481/F-2,产生环孢菌素C,产生环孢菌素D,产生环孢菌素E,产生环孢菌素G,产生环孢菌素合成酶,产生二氢环孢菌素C,产生二氢环孢菌素G,产生异环孢菌素G,产生脂肪酶,转换主机 |
| 菌株特点: |
ATCC 34921 Tolypocladium inflatum,丝状真菌
Nucleotide (GenBank) : Z69598 CPA-element
Nucleotide (GenBank) : AJ295083 5.8S rRNA and ITS2
Nucleotide (GenBank) : Z28383 cyclosporin synthetase gene
Nucleotide (GenBank) : A36768 Sequence 1 from Patent EP0578616.
Nucleotide (GenBank) : A36772 Sequence 5 from Patent EP0578616.
Nucleotide (GenBank) : A40404 Sequence 31 from Patent WO9425606.
Nucleotide (GenBank) : A40406 Sequence 33 from Patent WO9425606.
Nucleotide (GenBank) : A40408 Sequence 35 from Patent WO9425606.
Nucleotide (GenBank) : A40409 Sequence 36 from Patent WO9425606.
Nucleotide (GenBank) : A40410 Sequence 37 from Patent WO9425606.
Nucleotide (GenBank) : S80937 lamda clone 6-14, repetitive element
Nucleotide (GenBank) : AJ251864 partial tnir1 gene for pathway-specific nitrogen regulator, exons 1-2
Nucleotide (GenBank) : AOHE00000000 Tolypocladium inflatum NRRL8044, whole genome shotgun sequencing project
|
| 参考文献: |
Offenzeller M, et al. Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. J. Biol. Chem. 268: 26127-26134, 1993. PubMed: 8253730
Ruegger A, Kuhn M. Dihydrocyclosporin C. US Patent 4,108,985 dated Aug 22 1978
Harri E, Ruegger A. Organic compounds. US Patent 4,117,118 dated Sep 26 1978
Traber RP, et al. Cyclosporin derivatives, their production and pharmaceutical compositions containing them. US Patent 4,288,431 dated Sep 8 1981
Weber G, et al. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26: 120-125, 1994. PubMed: 8001164
Weber G, Leitner E. Disruption of the cyclosporin synthetase gene of Tolypocladium niveum. Curr. Genet. 26: 461-467, 1994. PubMed: 7874740
von Arx JA. Tolypocladium, a synomym of Beauveria. Mycotaxon 25: 153-158, 1986.
Kempken F, et al. A unique repeated DNA sequence in the cyclosporin-producing strain of Tolypocladium inflatum (ATCC 34921). Exp. Mycol. 19: 305-313, 1995. PubMed: 8574905
Agathos SN, Lee J. Mathematical modeling of the production of cyclosporin A by Tolypocladium inflatum: effect of L-valine. Biotechnol. Prog. 9: 54-63, 1993. PubMed: 7763411
Kempken F, Kuck U. Evidence for circular transposition derivatives from the fungal hAT-transposon Restless. Curr. Genet. 34: 200-203, 1998. PubMed: 9745022
Lee TH, et al. Development of a cell-loaded biosupport separator for continuous immobilized-cell perfusion culture. Biotechnol. Prog. 15: 267-272, 1999. PubMed: 10194403
Ruegger A, et al. Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity. Helv. Chim. Acta 59: 1075-1092, 1976. PubMed: 950308
Traber R, et al. New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E. Helv. Chim. Acta 60: 1568-1578, 1977. PubMed: 561044
Hoppert M, et al. Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladiium inflatum. Arch. Microbiol. 176: 285-293, 2001. PubMed: 11685373
Lee J, Agathos SN. Effect of amino acids on the production of cyclosporin A by Tolypocladium inflatum. Biotechnol. Lett. 11: 77-82, 1989.
Aarnio TH, Agathos SN. Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnol. Lett. 11: 759-764, 1989.
Windhofer F, et al. Ds-like restless deletion derivatives occur in Tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum. Fungal Genet Biol 35: 171-182, 2002. PubMed: 11848679
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