| 出品公司: | ATCC |
|---|---|
| 菌种名称: | ATCC9245, ATCC 9245 |
| 菌种又名: | 296 [CBS 167.53, DSM 1908, DSM 835, IMI 314507, NRRL 2310] |
| 菌株类型: | 雅致小克银汉霉;绮丽小克银汉霉;小克银汉霉菌Cunninghamella elegans |
| 存储人: | VM Cutter |
| 分离来源: | 亚麻籽，加拿大马尼托巴州温克勒市亚麻籽 |
| 产品目录号: | 9245 |
| 其他保藏库编号: | BCRC31841，ATCC 9245 ;CBS 167.53 ;DSM 1908 ;DSM 835 ;NRRL 2310;IMI 314507;VKM F-995 |
| 培养基: |
ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 323: Malt agar medium
ATCC® Medium 336: Potato dextrose agar (PDA)
|
| 生长条件: | 24-26℃, 有氧 |
| 生物安全等级: | 1 |
| 模式菌株: | 否 |
| 应用: |
科研，生产，主要用于水解sclareol，生产9,10-二甲基-1,2-苯并蒽7,12-二甲基苯并[a]蒽，产生肌钙蛋白，生产卡霉素衍生物马格霉素衍生物，产生亮霉素衍生物，生产尼达霉素衍生物，产生类固醇
，转化阿莫沙平，转换阿扎他定，转化溴苯那敏，转化扑尔敏，转化氯丙嗪，转化甲基二嗪，转换苯那敏，转化茄碱，阿莫沙平转化为7-羟基阿莫沙平，倍半萜内酯-科斯图内酯的转化，藤架改为藤架亚砜
|
| 菌株特点: |
ATCC 9245是雅致小克银汉霉,Cunninghamella elegans 。Nucleotide (GenBank) : M36310 Cunninghamella elegans 5S ribosomal RNA. |
| 参考文献: |
Bloom BM, Shull GM. Epoxidation of unsaturated steroids by microorganisms. J. Am. Chem. Soc. 87: 5767-5768, 1965.
Wong LK, et al. Metabolism of 7,12-dimethylbenz[a]anthracene by Cunninghamella elegans. Appl. Environ. Microbiol. 46: 1239-1242, 1983. PubMed: 6418073
Theriault RJ. Mycarosyl macrolide antibiotics. US Patent 3,784,447 dated Jan 8 1974
Wolf-Rainer A. Microbial hydroxylation of sclareol. Phytochemistry 36: 1421-1424, 1994.
Zhang D, et al. Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans. Appl. Environ. Microbiol. 62: 798-803, 1996. PubMed: 8975609
Hansen EB Jr., et al. Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N- demethylated metabolites by the fungus Cunninghamella elegans. Xenobiotica 25: 1081-1092, 1995. PubMed: 8578764
Zhang D, et al. Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. Appl. Environ. Microbiol. 62: 3477-3479, 1996. PubMed: 8795241
Moody JD, et al. Transformation of amoxapine by Cunninghamella elegans. Appl. Environ. Microbiol. 66: 3646-3649, 2000. PubMed: 10919836
Betts RE, et al. Microbial transformations of antitumor compounds. I. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata. J. Med. Chem. 17: 599-602, 1974. PubMed: 4829940
Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979.
Smith RV, et al. Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone. J. Pharm. Sci. 72: 733-736, 1983. PubMed: 6684155
Patel AV. Transformations of solasodine and derivatives of hecogenin by Cunninghamella elegans. Phytochemistry 35: 125-133, 1994.
Walther G, et al. DNA barcoding in Mucorales: an inventory of biodiversity. Persoonia 30: 11-47, 2013. PubMed: 24027345
Vitale RG, et al. Antifungal susceptibility and phylogeny of opportunistic members of the order Mucorales. J Clin Microbiol 50: 66-75, 2012. PubMed: 22075600
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