pro-BDNF细胞因子

价格:

规格: 10ug 50ug

联系方式:I47-825O-882O

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BDNF细胞因子产品基本信息

产品名称: 重组人脑源性神经营养因子
产品又名: BDNF细胞因子, BDNF细胞因子
英文名称: Brain-Derived Neurotrophic Factor; BDNF; Abrineurin
产品说明: 重组人脑源性神经营养因子是由我们的大肠杆菌表达系统和目标基因的Ala19-Arg 247表达。
背景说明: 脑源性神经营养因子的前体形式优先与泛神经营养素受体p75(P75NTR)和含vps10p结构域的受体山梨醇相互作用,诱导神经元凋亡,成熟的BDNF选择性地与TrkB激酶受体结合,促进神经元的存活、生长和分化。当前神经营养因子和成熟神经营养因子产生相反的生物学效应时,神经元系统中亲-BDNF的断裂是以特定和细胞上下文依赖的方式调控的。前BDNF在脑内神经营养作用的负调节中起着重要作用.
级别: AR
品牌: ELITE-MEDIA
产品目录号: P23560
产品规格: 10ug、50ug
产品外观: 乳白色均一粉末。
制剂: 冻干从0.2μm过滤液20 mm PB,250 mm NaCl,pH 7.2。
保存条件:
冻干蛋白应保存在<-20°C,室温下保存3周。
重组蛋白溶液可在4-7℃保存2~7d。
重组样品在<-20℃温度下稳定3个月。
 质量控制:
纯度:通过减少SDS-PAGE而确定的95%以上。
生物活性:固定化人前BDNF(Cat#C 077)在2μg/ml(100μl/孔)时能与人TrkB-His(Cat#C 507)结合,人亲BDNF(Cat#C 077)的ED 50为0.5~4μg/ml。
内毒素:LAL法测定小于0.1ng/g(1 Eu/?g)。
注意事项: 避免呼入和皮肤接触。
文献引用:
Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin Aurélien Briens, et al. (cell discovery, 2017)
Estudio clínico-epidemiológico y molecular del temblor familiar Bergarecha Yarza, et al. (2017)
SORT1 mutation resulting in sortilin deficiency and p75NTR upregulation in a family with essential tremor Sánchez E, et al. (ASN neuro, 2015)
BDNF and pro-BDNF in serum and exosomes in major depression: Evolution after antidepressant treatment. Gelle, Samey, Plansont, Bessette, Jauberteau-Marchan, Lalloué, Girard, Prog Neuropsychopharmacol Biol Psychiatry(2021 Jul 13) 
Retraction notice to "Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process" [Heliyon (2021) e06219]. Taghizadeh, Maghsoudi, Manaheji, Akparov, Baniasadi, Mohammadi, Danyali, Ghasemi, Zaringhalam, Heliyon(2021 May) 
7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway. Fang, Luo, Yue, Han, Zhang, Zhou, Liu, Liu, Sleep Breath(2021 May 15) 
The impact of antipsoriatic treatment on serum pro-BDNF, BDNF levels, depression, anxiety scores, and quality of life. Aksoy, Ergun, Akkiprik, Peker Eyuboglu, Seckin Gencosmanoglu, Cöbek Ünalan, Yöney, Dermatol Ther(2021 03) 
Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction. Gilchrist, Cumberland, Kondos-Devcic, Hill, Khore, Quezada, Reichelt, Tolcos, Hippocampus(2021 Mar) 

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