TGFB1细胞因子

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规格: 10ug 50ug

联系方式:I47-825O-882O

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CED细胞因子产品基本信息

产品名称: 重组小鼠转化生长因子β-1
产品又名: CED细胞因子, CED细胞因子
英文名称: TGF-beta-1; CED; DPD1; TGFB; TGF-b1; TGFB1; CEDLAP;latency-associated peptide; TGFbeta; TGF-beta 1 protein; transforming growth factor beta-1
产品说明: 重组小鼠转化生长因子β1(TransformingGrowthFactorβ1)由哺乳动物表达系统产生,目的基因Ala279-Ser390得到表达。
背景说明: 转化生长因子β1(TGFβ1)是肽生长因子超家族的原型,在细胞周期进展、细胞分化、生殖功能、发育、运动、粘附、神经元生长、骨形态发生、伤口愈合和免疫监测等多种细胞过程中发挥着重要作用。转化生长因子-β1、转化生长因子-β2和转化生长因子-β3信号通过相同的异聚受体复合物,由配体结合的转化生长因子-β受体Ⅱ型(TβR-II)和转化生长因子-β受体Ⅰ型(TβR-I)组成。从受体到细胞核的信号转导是通过Smad介导的。TGF-β在软骨、骨、牙齿、肌肉、心脏、血管、造血细胞、肺、肾、肠、肝、眼、耳、皮肤和神经系统中均有表达。
级别: AR
品牌: ELITE-MEDIA
产品目录号: P04202
产品规格: 10ug、50ug
产品外观: 乳白色均一粉末。
制剂: 冻干从0.2μm过滤液4mmHCl。
保存条件:
冻干蛋白应保存在<-20°C,室温下保存3周。
重组蛋白溶液可在4-7℃保存2~7d。
重组样品在<-20℃温度下稳定3个月。
 质量控制:
纯度:通过减少SDS-PAGE而确定的95%以上。
生物活性:测定其抑制TF-1人红白血病细胞IL-4依赖性增殖的能力,其ED 50为5~25 pg/ml。
内毒素:LAL法测定小于0.1ng/g(1 Eu/?g)。
注意事项: 避免呼入和皮肤接触。
文献引用:
The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-smal Yang Zhang, et al. ( Respiratory Research , 2019)
Glycoprotein M6B Interacts with TβRI to Activate TGF‐β‐Smad2/3 Signaling and Promote Smooth Muscle Cell Differentiation Xiaomeng Zhang, et al. (STEM CELLS, 2018)
T RII Regulates the Proliferation of Metanephric Mesenchyme Cells through Six2 In Vitro Zhaomin Mao , et al. (INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2017)
Type-1 Na+/H+ exchanger is a prognostic factor and associate with immune infiltration in liver hepatocellular carcinoma. Zhou, Chen, Ai, Li, Li, Zhao, Cai, Hou, Ni, Xu, Qiu, Life Sci(2021 Aug 01) 
Patchouli alcohol improves wound healing in high fat diet-fed mice through AMPK-mediated suppression of inflammation and TGFb1 signaling. Kim, Pyun, Park, Lee, Abd El-Aty, Song, Shin, Jeong, Jung, Biochem Biophys Res Commun(2021 Jul 05) 
Estrogen deficiency affects tooth formation and gene expression in the odontogenic region of female rats. Küchler, de Lara, Omori, Schröder, Teodoro, Baratto-Filho, Léon, Proff, Madalena, Kirschneck, Ann Anat(2021 Jul) 
Periplocymarin protects against myocardial fibrosis induced by β-adrenergic activation in mice. Yun, Qian, Yuan, Xu, Biomed Pharmacother(2021 Jul) 
CXCL8 expression and methylation are correlated with anthropometric and metabolic parameters in childhood obesity. Lima, Mattos, Medeiros, Kattah, Nascimento, Menezes, Rios-Santos, Dutra, Gomes, Moreira, Cytokine(2021 Jul) 

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