产品名称: | 重组人胰岛素样生长因子I |
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产品又名: | IBP1细胞因子, IBP1细胞因子 |
英文名称: | Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1 |
产品说明: | 重组人胰岛素样生长因子I(4-70)在大肠杆菌表达系统中得到表达,目的基因编码Thr52-Ala118。 |
背景说明: | 胰岛素样生长因子I(IGF 1)属于胰岛素样生长因子家族,与胰岛素原具有结构同源性。成熟的IGFS是通过对含有N端和C端前体区的非活性前体蛋白进行蛋白水解而产生的。成熟的人IGF-Ⅰ由70个氨基酸组成,与小鼠IGF 1的同源性为94%,具有跨物种活性。IGF 1与胰岛素受体IGF-1R、IGF-2R及胰岛素受体结合,在细胞周期进程、细胞增殖和肿瘤发展中起关键作用。IGF 1的表达受生长激素的调节。 |
级别: | AR |
品牌: | ELITE-MEDIA |
产品目录号: | P05019 |
产品规格: | 10ug、50ug |
产品外观: | 乳白色均一粉末。 |
制剂: | 冻干从0.2μm过滤液20 mm HAC-NAAC,pH 4.5. |
保存条件: |
冻干蛋白应保存在<-20°C,室温下保存3周。
重组蛋白溶液可在4-7℃保存2~7d。
重组样品在<-20℃温度下稳定3个月。
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质量控制: |
纯度:通过减少SDS-PAGE而确定的95%以上。
生物活性:用MCF-7人乳腺癌细胞进行无血清细胞增殖试验,测得此效应的ED 50为20-100ng/ml。
内毒素:LAL法测定小于0.1ng/g(1 Eu/?g)。
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注意事项: | 避免呼入和皮肤接触。 |
文献引用: |
A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in hu Song L, et al. (Food & function, 2016)
The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes. Sawa, Wake, Yamamoto, Okimura, Growth Horm IGF Res(2021 Aug)
Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men. Hatfield, Kraemer, Volek, Nindl, Caldwell, Vingren, Newton, Häkkinen, Lee, Maresh, Hymer, Growth Horm IGF Res(2021 Aug)
Stimulated GH levels during the transition phase in Prader-Willi syndrome. Grugni, Marzullo, Delvecchio, Iughetti, Licenziati, Osimani, Ragusa, Salvatoni, Sartorio, Stagi, Crinò, Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED), J Endocrinol Invest(2021 Jul)
Positive Association Between Serum Insulin-Like Growth Factor-1 and Cognition in Patients with Cerebral Small Vessel Disease. Kang, Luo, Zhang, Ren, Cao, Wu, Li, J Stroke Cerebrovasc Dis(2021 Jul)
Impact of simulated military operational stress on executive function relative to trait resilience, aerobic fitness, and neuroendocrine biomarkers. Beckner, Conkright, Eagle, Martin, Sinnott, LaGoy, Proessl, Lovalekar, Jabloner, Roma, Basner, Ferrarelli, Germain, Flanagan, Connaboy, Nindl, Physiol Behav(2021 Jul 01)
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