IL-10RB细胞因子

价格:

规格: 10ug 50ug

联系方式:I47-825O-882O

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IL10RB细胞因子产品基本信息

产品名称: 重组人IL-10受体亚基β
产品又名: IL10RB细胞因子, IL10RB细胞因子
英文名称: Interleukin-10 receptor subunit beta(IL10RB);Cytokine receptor class-II member 4;Cytokine receptor family 2 member 4;Interleukin-10 receptor subunit 2;
产品说明: 重组人白细胞介素-10受体β亚基是由我们的哺乳动物表达系统和目标基因的Met20-Ser220表达与FC标签在C-末端。
背景说明: 白细胞介素-10受体亚单位β(IL10RB)又称细胞因子受体Ⅱ类成员4、细胞因子受体家族2成员4、白细胞介素-10受体亚基2,属于Ⅱ型细胞因子受体家族。IL10RB是一种单程Ⅰ型膜蛋白,含有两个纤维连接蛋白Ⅲ型结构域。它是活性白细胞介素10受体复合物所必需的一条附属链。IL10Rb和IL10RA蛋白的共表达在IL 10诱导的信号转导中被证明是必需的。IL10RB的缺陷是引起炎症性肠病25型(IBD 25)的原因,IBD 25是一种慢性复发性胃肠道炎症,病因复杂。
级别: AR
品牌: ELITE-MEDIA
产品目录号: Q08334
产品规格: 10ug、50ug
产品外观: 乳白色均一粉末。
制剂: 冻干从0.2μm过滤的PBS溶液中,pH值为7.4。
保存条件:
冻干蛋白应保存在<-20°C,室温下保存3周。
重组蛋白溶液可在4-7℃保存2~7d。
重组样品在<-20℃温度下稳定3个月。
 质量控制:
纯度:通过减少SDS-PAGE而确定的95%以上。
内毒素:LAL法测定小于0.1ng/g(1 Eu/?g)。
注意事项: 避免呼入和皮肤接触。
文献引用:
IFN-λ Modulates the Migratory Capacity of Canine Mammary Tumor Cells via Regulation of the Expression of Matrix Metalloproteinases and Their Inhibitors. Pingwara, Kosmala, Woźniak, Orzechowski, Mucha, Cells(2021 Apr 23) 
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. Gaziano, Giambartolomei, Pereira, Gaulton, Posner, Swanson, Ho, Iyengar, Kosik, Vujkovic, Gagnon, Bento, Barrio-Hernandez, Rönnblom, Hagberg, Lundtoft, Langenberg, Pietzner, Valentine, Gustincich, Tartaglia, Allara, Surendran, Burgess, Zhao, Peters, Prins, Angelantonio, Devineni, Shi, Lynch, DuVall, Garcon, Thomann, Zhou, Gorman, Huffman, O'Donnell, Tsao, Beckham, Pyarajan, Muralidhar, Huang, Ramoni, Beltrao, Danesh, Hung, Chang, Sun, Joseph, Leach, Edwards, Cho, Gaziano, Butterworth, Casas, VA Million Veteran Program COVID-19 Science Initiative, Nat Med(2021 04) 
Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages. Hoffmann, Sens, Brennig, Brand, Philipp, Vollmer Barbosa, Kuehle, Steinemann, Lenz, Buchegger, Morgan, Falk, Klein, Lachmann, Schambach, J Pers Med(2021 Mar 20) 
Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies. Sens, Hoffmann, Lange, Vollmer Barbosa, Morgan, Falk, Schambach, Hum Gene Ther(2021 Jan) 
Biomarkers of Inflammation and Glomerular Filtration Rate in Individuals with Recent-Onset Type 1 and Type 2 Diabetes. Maalmi, Herder, Strassburger, Urner, Jandeleit-Dahm, Zaharia, Karusheva, Bongaerts, Rathmann, Burkart, Szendroedi, Roden, J Clin Endocrinol Metab(2020 12 01) 

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