菌种名称: | H37Rv |
---|---|
出品公司: | ATCC |
产品编号: | 25618, ATCC25618,27294,ATCC27294 |
中文名称: | H37Rv结核杆菌, H37Rv结核菌,H37Rv结核分枝杆菌,H37Rv结核分歧杆菌,H37Rv分枝杆菌,H37Rv分歧杆菌,H37RV肺结核菌 |
英文名称: |
Mycobacterium tuberculosis
|
培养基: | Middlebrook 7H9肉汤和ADC营养添加剂 |
生长条件: | 37℃, 有氧,这个菌生长缓慢,37度条件下,需要静置15-20天周才能长出。 |
生物安全等级: | 3 |
分离来源: |
Derived from E.R. Baldwin's human-lung isolate H37 by W. Steenken New York, United States, 1934
|
分离日期: | 1934年 |
应用: | 药物敏感性测试,药物研究,肺结核疾病研究。 |
是否模式菌种: | 不是 |
基因组数据: | 结核杆菌H37Rv全基因组序列 |
参考文献: |
Maruyama C. Immunotherapeutic agent for tumors comprising lipopolysaccharide as an active component. US Patent 4,394,502 dated Jul 19 1983
. . J. Exp. Med. 60: 515-540, 1934.
Runyon EH, et al. Mycobacterium tuberculosis, M. bovis and M. microti species descriptions. Zentralbl. Bakteriol., I Abt., Orig. 204: 405-413, 1967.
Klemens SP, et al. Therapy of multidrug-resistant tuberculosis: lessons from studies with mice. Antimicrob. Agents Chemother. 37: 2344-2347, 1993. PubMed: 8285617
Newton GL, et al. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J. Bacteriol. 178: 1990-1995, 1996. PubMed: 8606174
Li Z, et al. Rapid detection of Mycobacterium avium in stool samples from AIDS patients by immunomagnetic PCR. J. Clin. Microbiol. 34: 1903-1907, 1996. PubMed: 8818878
Hackbarth CJ, et al. Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra. Antimicrob. Agents Chemother. 41: 1182-1185, 1997. PubMed: 9145897
|
DNA序列: |
Nucleotide (GenBank) : AL123456.3 Mycobacterium tuberculosis H37Rv complete genome
Nucleotide (GenBank) : U06258 Mycobacterium tuberculosis ATCC 25618 catalase (katG) gene, complete cds.
|
菌株说明: |
1. H37Rv具有A型beta内酰胺酶活性。 2. H37Rv结核杆菌的全基因组序列已经测序完成。 3. H37Rv是目前最常用的肺结核疾病研究中使用的模式菌种,被广泛用于结核菌的科学研究。 4. H37Rv是结核分枝杆菌标准有毒株, H37Ra是从H37Rv获得的稳定减毒株。 5. 人型结核分支杆菌H37Rv是结核病的主要病原菌, 但至今人们对其致病分子机理仍然了解甚少。 |